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. Author manuscript; available in PMC: 2011 May 13.
Published in final edited form as: J Med Chem. 2010 May 13;53(9):3594–3601. doi: 10.1021/jm901857d

Table 1. Standards.

graphic file with name nihms194521u1.jpg
Compound IC50a (μM) TD50a (μM) TIa Log TI
Trimethoprim 46 ≥320b 12 1.1
Artemisinin 0.64 ≥320 879 2.9
Artemether 0.31 ≥320 1814 3.2

Legend for Tables 1-4.

a

IC50, median inhibitory concentration; TD50, median cytotoxic dose; TI, therapeutic index determined by TD50/IC50.

b

Cytotoxicity endpoint not reached; a value of ¼ log10 greater than the highest concentration tested was used to compute the TI.

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