Table 3.

Western Blotting Results for Selected GABA Receptor Genes and β-Actin in BA9, BA40, and Cerebellum

BA9	Control	Autistic	Change	P
GABRα4 / β-Actin	0.058 ± 0.007	0.040 ± 0.004	↓ 31%	0.0086
GABRα5 / β-Actin	0.576 ± 0.040	0.288 ± 0.176	↓ 50%	0.035
GABRβ1 / β-Actin (58 kDa)	0.198 ± 0.05	0.095 ± 0.021	↓ 52%	0.012
GABRβ1 / β-Actin (55 kDa)	0.213 ± 0.058	0.100 ± 0.021	↓ 53%	0.014
GABBR1/ β-Actin1	0.076 ± 0.023	0.023 ± 0.024	↓ 70%	0.021
β-Actin	30.4 ± 1.38	27.8 ± 2.85	↓ 8.5%	ns
Age ± SD (years)	26.0 ± 5.29	23.8 ± 5.29	↓ 8.4%	ns
PMI ± SD (years)	20 ± 4.0	17.7 ± 7.15	↓ 11%	ns
Gender	3M:0F	4M:1F	-	--
BA40	Control	Autistic	Change	P
GABRα4 / β-Actin	0.195 ± 0.039	0.230 ± 0.045	↑ 18%	ns
GABRα5 / β-Actin	0.439 ± 0.118	0.217 ± 0.024	↓ 51%	0.01
GABRβ1 / β-Actin (58 kDa)	0.278 ± 0.213	0.213 ± 0.139	↓ 23%	ns
GABRβ1 / β-Actin (55 kDa)	0.315 ± 0.112	0.270 ± 0.049	↓ 14%	ns
GABBR1/ β-Actin1	0.078 ± 0.049	0.023 ± 0.026	↓ 71%	0.019
β-Actin	15.6 ± 1.16	13.9 ± 2.14	↓ 11%	ns
Age ± SD (years)	23.6 ± 5.03	22.8 ± 3.59	↓ 3.4%	ns
PMI ± SD (years)	18.4 ± 6.02	16.6 ± 2.82	↓ 9.8%	ns
Gender	5M:0F	3M:1F	-	--
Cerebellum	Control	Autistic	Change	P
GABRα4 / β-Actin	0.066 ± 0.021	0.054 ± 0.015	↓ 18%	ns
GABRα5 / β-Actin	0.387 ± 0.194	0.436 ± 0.152	↑ 13%	ns
GABRβ1 / β-Actin (58 kDa)	0.216 ± 0.038	0.195 ± 0.035	↓ 9.7%	ns
GABRβ1 / β-Actin (55 kDa)	0.444 ± 0.106	0.425 ± 0.129	↓ 4.3%	ns
GABBR1/ β-Actin1	0.051 ± 0.019	0.017 ± 0.006	↓ 67%	0.0049
β-Actin	20.0 ± 1.43	20.1 ± 2.21	↑ 0.5%	ns
Age ± SD (years)	26.36 ± 10.63	24.86 ± 4.67	↓ 5.7%	ns
PMI ± SD (years)	18.0 ± 5.98	16.16 ± 6.81	↓1.8%	ns
Gender	10M:1F	6M:1F	-	--

¹Values for GABBR1 are reprinted with kind permission from Springer Science+Business Media: Cerebellum, Expression of GABA(B) Receptors Is Altered in Brains of Subjects with Autism, volume 8, 2009, page 67, Fatemi SH, Folsom TD, Reutiman TJ, Thuras PD, Table 2. ns, not significant