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(A) IL-1β (0–10 ng/mL) induced NO production of end-plate chondrocytes in a dose-dependent manner. (B) Muscone suppressed IL-1β-induced NO production in a dose-dependent manner. (C) Muscone downregulated IL-1β-induced iNOS mRNA expression in a dose-dependent manner. Values are shown as means (bars) + SDs (error bars) of three independent experiments.
