Table 3.
Associations of KITLG and SPRY4 SNP markers with seminoma and non-seminoma TGCTa
| Seminoma OR (95% CI) | Non-Seminoma OR (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Marker | Risk allele | Per allele | Heterozygoteb | Homozygotec | Per allele | Heterozygoteb | Homozygotec |
| KITLG | rs4474514 A/G | A | 2.97 (2.08, 4.23) | 1.42 (0.42, 4.87) | 4.70 (1.44, 15.4) | 3.27 (2.06, 5.18) | 1.13 (0.25, 5.1) | 4.34 (1.03, 18.23) |
|
| ||||||||
| KITLG | rs3782179 A/G | A | 2.95 (2.07, 4.21) | 1.42 (0.42, 4.87) | 4.67 (1.43, 15.3) | 3.30 (2.08, 5.24) | 1.13 (0.25, 5.1) | 4.39 (1.04, 18.45) |
|
| ||||||||
| SPRY4 | rs6897876 C/T | C | 1.38 (1.11, 1.72) | 1.11 (0.72, 1.73) | 1.78 (1.14, 2.79) | 1.39 (1.07, 1.81) | 0.72 (0.43, 1.2) | 1.55 (0.93, 2.56) |
|
| ||||||||
| SPRY4 | rs4324715 T/C | T | 1.40 (1.13, 1.73) | 1.39 (0.92, 2.09) | 1.98 (1.27, 3.09) | 1.32 (1.01, 1.71) | 0.83 (0.52, 1.32) | 1.60 (0.97, 2.62) |
a
Analyses reflect the replication set only
b
OR for heterozygous carriage of risk allele compared to homozygous carriage of non-risk allele.
c
OR for homozygous carriage of risk allele compared to homozygous carriage of non-risk allele