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. 2010 May;21(5):803–810. doi: 10.1681/ASN.2009040353

Figure 2.

Figure 2.

Overexpression of Notch2 in embryonic nephron progenitors leads to severe kidney dysgenesis. (A) Kidneys in a newborn wild-type mouse (P0). k, kidney; t, testis; b, bladder; a, adrenal gland. (B) Kidney size is reduced in a newborn Six2Cre/R26Notch2 mouse (P0). (C and D) HE staining of newborn kidneys. Severe dysgenesis is observed in the Six2Cre/R26Notch2 kidney. Arrowheads show glomerular cysts. (E and F) Immunostaining for Lotus tetragonobulus lectin (LTL; green; proximal tubule marker) and cytokeratin 8 (CK8; red; ureteric bud marker). The upper right panels show higher-magnification images of the dotted square regions. They are ×2 of the original panels. Proximal tubules are not overproduced under Notch2 activation. Arrows, dilated proximal tubules. Scale bar = 100 μm.