Table 1.
Control | Diabetes |
||||
---|---|---|---|---|---|
Sham | Ad-Null | Ad-S1 | Ad-S3 | ||
Blood glucose (mg/dl) | 95 ± 8 | 581 ± 8a | 567 ± 20a | 576 ± 18a | 587 ± 9a |
Body weight (g) | 283 ± 13 | 209 ± 14a | 196 ± 7a | 235 ± 15a,b | 230 ± 14a,b |
Creatinine clearance (ml/min/kg) | 1.42 ± 0.28 | 3.34 ± 0.26a | 3.23 ± 0.17a | 2.01 ± 0.14b | 2.12 ± 0.22b |
Urinary albumin (mg albumin/mg creatinin) | 0.19 ± 0.04 | 9.72 ± 3.16a | 9.47 ± 1.48a | 2.76 ± 0.64a,b | 4.75 ± 1.07a,b |
Kidney-to-body-weight ratio (g/kg) | 8.87 ± 0.43 | 12.90 ± 0.57a | 13.41 ± 0.77a | 9.71 ± 1.07b | 9.42 ± 0.85b |
Glomerular volume (μm3 × 106) | 0.45 ± 0.03 | 1.04 ± 0.06a | 1.00 ± 0.03a | 0.69 ± 0.04a,b | 0.61 ± 0.05a,b |
aP < 0.05 versus control nondiabetic rats.
bP < 0.05 versus sham-operated diabetic rats.