Table 4. Worst non-haematological drug-related toxicity per patients (all cycles).
| Treatment arm |
Number of patients
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Carboplatin arm
|
Paclitaxel arm
|
Triplet arm
|
|||||||
| CTCAE grade Toxicity | 1 | 2 | 3 | 1 | 2 | 3 | 1 | 2 | 3 |
| Fatigue | 4 | 5 | 3 | 5 | 7 | — | 3 | 5 | — |
| Pain | 6 | 4 | 2 | 2 | 8 | 2 | 1 | 5 | 0 |
| Sensory neuropathy | 6 | — | 1 | 8 | 1 | 1 | 5 | 3 | — |
| Alopecia | — | — | — | 2 | 12 | — | 1 | 7 | — |
| Nausea | 4 | 5 | — | 4 | 2 | — | 3 | 4 | — |
| Pain – headache | 1 | 5 | 1 | 3 | 1 | — | 1 | 4 | — |
| QTc prolongation | 3 | — | — | 7 | 2 | — | 2 | 1 | — |
| Vomiting | 3 | 2 | 1 | 3 | 3 | — | — | 2 | — |
| Hypertension | 3 | 2 | — | 1 | 2 | — | 3 | — | 1 |
| Constipation | — | 4 | — | 1 | 4 | — | — | 2 | — |
| Diarrhoea | 2 | 1 | 3 | 1 | 1 | — | 2 | 3 | |
| Pyrexia | 3 | — | — | 5 | 2 | — | 1 | — | — |
| Flushing | 3 | 1 | — | 1 | — | — | 2 | 1 | — |
| Hypotension | — | 1 | — | 1 | 3 | — | 1 | 2 | — |
| Itching | 3 | — | — | 1 | — | — | 4 | — | — |
| Anorexia | 1 | 1 | — | — | — | — | 4 | 1 | — |
| Infection | — | 1 | — | — | 1 | 2 | 2 | 1 | — |
| Myalgia | 1 | — | — | 3 | — | — | 2 | 1 | — |
| Neurological: muzzy head | 2 | — | — | 2 | — | — | 1 | — | — |
| Oedema | 2 | 1 | — | 1 | 1 | — | — | — | — |
| Perianal itching | 3 | — | — | 1 | — | — | 1 | — | — |
| Rash | — | 1 | — | 1 | 1 | 2 | — | — | — |
| Stomatitis | 1 | — | — | 1 | 1 | — | 2 | — | — |
| Tachycardia | 1 | — | — | 2 | — | — | 2 | — | — |
| Agitation | 2 | — | 1 | 1 | — | — | — | — | — |
| Cough | — | 1 | — | 1 | — | 1 | — | — | — |
| Motor neuropathy | — | 1 | 1 | — | — | 1 | — | — | — |
| Allergy | — | — | 1a | — | — | 1 | 1 | — | — |
| Ataxia | — | — | — | — | — | — | — | 1 | 1 |
| Dysphasia | — | 1 | 1 | — | — | — | — | — | — |
| Dehydration | — | — | — | — | — | 1 | — | — | — |
| Incontinence | — | — | 1 | — | — | — | — | — | — |
| Sepsis | — | — | 1 | — | — | — | — | — | — |
Abbreviation: CTCAE=common terminology criteria for adverse events.
a
Grade 4 toxicity.