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. 2010 Apr 13;102(9):1371–1377. doi: 10.1038/sj.bjc.6605653

Figure 2.

Figure 2

The distribution of baseline total bilirubin (TBL) and maximum TBL by UGT1A1 TA-repeat genotype for pazopanib-treated white patients from both Study 1 and Study 2. The maximum bilirubin value for one patient who had the TA7/TA7 genotype was truncated from 19 × upper limit of normal (ULN) to 6 × ULN for viewing purposes. The number of patients with each genotype, and the median values for baseline TBL, maximum TBL, and maximum change-from-baseline (delta) TBL are provided. The variation in baseline TBL, maximum TBL, and change-from-baseline TBL by genotype is statistically significant for each end point: P=4.0 × 10−3, 1.6 × 10−6, and 4.5 × 10−5, respectively.