TABLE 1.
COMPOSITION OF FAST DISINTEGRATING TABLETS OF PROCHLORPERAZINE MALEATE
| Ingredients (mg/ tablet) | Formulation Code* | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| EC0 | ECP1 | ECP2 | ECP3 | ECP4 | ECCS1 | ECCS2 | ECCS3 | ECCS4 | |
| Prochlorperazine Maleate | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 |
| Sodium bicarbonate | 22.5 | 22.5 | 15.0 | 22.5 | 30.0 | 22.5 | 15.0 | 22.5 | 30.0 |
| Citric acid | 15.0 | 15.0 | 7.5 | 15.0 | 22.5 | 15.0 | 7.5 | 15.0 | 22.5 |
| Crospovidone | -- | -- | 3.0 | 9.0 | 15.0 | -- | -- | -- | -- |
| Crosarmellose sodium | -- | -- | -- | -- | -- | -- | 3.0 | 9.0 | 15.0 |
| Microcrystalline cellulose | -- | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 | 30.0 |
| Aspartame | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Talc | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 | 3.0 |
| Sodium stearyl fumarate | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Pineapple flavor | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 | 1.5 |
| Pearlitol SD-200 | 100.0 | 70.0 | 82.0 | 61.0 | 40.0 | 70.0 | 82.0 | 61.0 | 40.0 |
*
A batch of 60 tablets was prepared for each formulation