TABLE 2.
EVALUATION OF FAST DISINTEGRATING TABLETS
| Formulation Code | Parameters | |||||
|---|---|---|---|---|---|---|
| Hardness* (kg/cm2) | Thickness (mm) | Friability (%) | In vitro dispersion time* (Sec) | Percent drug content* (%) | Weight variation | |
| EC0 | 2.8±0.20 | 2.15 | 0.64 | 117.87±2.48 | 97.77±0.62 | (146 - 150 mg) within the IP limits of ±7.5% |
| ECP1 | 2.8±0.264 | 2.17 | 0.70 | 98.69±1.60 | 97.76±0.73 | |
| ECP2 | 2.83±0.152 | 2.36 | 0.55 | 59.79±1.63 | 99.03±0.78 | |
| ECP3 | 2.92±0.05 | 2.37 | 0.42 | 44.66±2.37 | 97.96±1.38 | |
| ECP4 | 2.63±0.25 | 2.41 | 0.49 | 13.29±1.02 | 95.68±0.59 | |
| ECCS1 | 2.83±0.20 | 2.34 | 0.60 | 104.97±2.40 | 101.14±1.30 | |
| ECCS2 | 2.64±0.305 | 2.39 | 0.64 | 62.42±0.90 | 101.27±0.74 | |
| ECCS3 | 2.76±0.305 | 2.73 | 0.54 | 51.47±0.66 | 99.42±1.02 | |
| ECCS4 | 2.64±0.208 | 2.40 | 0.50 | 20.42±1.25 | 99.46±0.71 | |
*
Average of three determinations. Formulations ECP4 and ECCS4 were selected as the best formulations and used for further studies.