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. 2010 May;11(5):315–322. doi: 10.1631/jzus.B0900364

Table 1.

Inhibitory effect of Jeju seaweeds on the production of pro-inflammatory mediators

Specimen number Scientific name Inhibition rate (%)
Phlorotannin content (µg/ml)
NO PGE2 IL-6 TNF-α Cytotoxicity
JBR243 Sargassum nipponicum 72.1±2.7** 86.2±0.8** 74.9±7.2** 90.0±2.6** 132.6±5.2 58.0
JBR256 Myelophycus simplex 81.9±0.3** 65.0±2.2** 74.5±4.5** 51.8±1.2** 103.5±1.6 33.0
JBR270 Chondrus ocellatus 78.2±0.3** 90.7±1.0** 83.1±2.4** 71.0±1.9** 106.1±12.4 37.2
JBR271 Ishige okamurae 30.8±0.9* NE 47.1±0.7* 3.1±0.8* 118.6±3.8 332.5
JBR274 Bonnemaisonia hamifera 81.8±0.1** NE 18.0±0.6** 73.8±0.0** 99.5±1.0 72.2
JBR345 Scytosiphon lomentaria 70.4±0.2** 89.9±1.5** 90.4±0.2** 55.2±0.3** 93.6±6.9 65.0
JBR354 Callophyllis crispata 83.6±0.0** 84.7±3.1** 90.4±0.5** 75.7±0.9** 79.7±5.9 40.0
JBR368 Padina arborescens 59.7±0.4** 80.5±0.9** 71.3±3.7** 80.9±0.7** 87.8±8.7 124.0
JBR375a Laurencia okamurae 82.4±0.1** 82.1±4.2** 76.9±0.7** 52.5±0.0** 91.4±2.4 37.3
JBR376 Chondria crassicaulis 75.7±0.0** 88.4±1.6** 84.8±0.6** 67.1±0.3** 87.5±5.3 54.7
JBR510b Grateloupia elliptica 78.2±0.4** 81.0±4.8** 85.7±0.8** 63.8±0.8** 89.4±6.9 47.7
JBR511b Sargassum thunbergii 77.3±0.2** 73.8±4.0** 46.9±4.4** 63.1±1.2** 98.0±3.7 44.8
JBR518b Gloiopeltis furcata 77.6±0.5** 85.6±0.6** 82.1±2.2** 70.9±1.3** 108.3±4.8 53.3
JBR538b Hizikia fusiformis 77.2±0.1** 81.0±4.8** 69.9±6.7** 61.5±3.9** 105.8±3.5 43.3

The presence of nitrite, as a stable oxidized product of NO, was determined in cell-culture media by a modified Griess method. The amounts of PGE2, TNF-α, and IL-6 in the cell-culture supernatant and serum were measured using an ELISA kit. RAW 264.7 cells were incubated with various concentrations of seaweed extracts (25a, 50b, or 100 µg/ml). Cell viability was determined by MTT assay. The data represent the mean±SD of triplicate experiments

*

P<0.05 vs. LPS alone

**

P<0.01 vs. LPS alone

NE: no effects