TABLE 2.
Predictors of Cognition: Neuroticism and Depression
| Dependent Variables | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MMSE | Mattis-IP | Trails A | Trails B | |||||||||
| Independent Variables | β (χ2) | 95%CI | p | β (χ2) | 95%CI | p | β (χ2) | 95%CI | P | β (χ2) | 95%CI | p |
| Neuroticism | −0.04 (14.2) | −0.07, −0.02 | 0.0002 | −0.03 (2.11) | −0.07, 0.01 | 0.15 | 0.09 (0.28) | −0.24, 0.42 | 0.60 | 0.40 (1.26) | −0.30, 1.11 | 0.26 |
| Dep Dx MDD | 0.21 (0.71) | −0.28, 0.69 | 0.40 | −0.19 (0.20) | −1.03, 0.65 | 0.65 | 7.86 (5.04) | 0.99, 14.73 | 0.02 | 16.20 (4.54) | 1.27, 31.14 | 0.03 |
| MinD | 0.16 (0.55) | −0.27, 0.60 | 0.46 | 0.45 (1.34) | −0.31, 1.22 | 0.25 | 1.91 (0.36) | −4.29, 8.11 | 0.55 | 0.37 (0.00) | −12.84, 13.59 | 0.96 |
| Neuroticism | −0.04 (8.97) | −0.06, −0.01 | 0.003 | −0.02 (1.32) | −0.07, 0.02 | 0.25 | 0.12 (0.48) | −0.23, 0.47 | 0.49 | 0.38 (1.00) | −0.37, 1.13 | 0.32 |
| Ham-D | −0.01 (0.13) | −0.04, 0.03 | 0.72 | −0.02 (0.42) | −0.07, 0.04 | 0.52 | 0.33 (2.14) | −0.11, 0.76 | 0.14 | 0.83 (3.03) | −0.11, 1.77 | 0.08 |
Note: All analyses covaried age, gender, years of education, and Cumulative Illness Rating Scale score. For depression diagnosis β reported for major depression (MDD) and minor depression (MinD), respectively. All analyses shown have one degree of freedom (df). P-values are reported for the associated Wald χ2 tests. MMSE: Mini-Mental State Examination; Mattis-IP: Mattis Dementia Rating Scale; Trails A: Trail-making test A; Trails B: Trail-making test B; N: Neuroticism; Dep Dx: Depression Diagnosis (MDD, MinD versus reference non-depressed group); Ham-D: Hamilton Rating Scale for Depression