Figure 2.

Increased membrane conductance introduced via a noisy process decreases the gain of CA1 pyramidal cells. A, Examples of voltage traces from a single CA1 pyramidal cell stimulated with a noisy input generated via an Ornstein–Uhlenbeck process. Left column shows examples of traces generated when the mean excitatory and inhibitory conductance were set to 0. In the right column, traces were generated with a tonic excitatory and inhibitory conductance of 2 and 8 nS, respectively (total of 10 nS). B, Plot of the steady-state f–I relationship for a single cell stimulated using an Ornstein–Uhlenbeck process with or without a conductance component (same cell as shown in A). Data points for each conductance level were fit using a linear regression (dashed lines) to calculate the gain of the f–I relationship. C, Plot of average normalized steady-state gain as a function of stimulus condition. For each condition, the gain was calculated using a linear regression analysis and then normalized to the control value.