Figure 3.

Increasing membrane conductance increases the magnitude of spike frequency adaptation in CA1 pyramidal cells. A, Example of voltage traces from a single CA1 cell generated in response to 4 s square current steps under control conditions and with 5, 10, and 15 nS of added conductance. Panels show the initial membrane voltage response to the current step (i) and steady-state response (ii). B, Plot of the adaptation ratio as a function of added conductance. Adaptation ratio was measured when cells fired at an approximate steady-state firing rate of 5 Hz and was normalized to control values for each cell.