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. Author manuscript; available in PMC: 2010 May 7.
Published in final edited form as: Nature. 2006 Mar 30;440(7084):684–687. doi: 10.1038/nature04538

Figure 3. TRP-4 functions in DVA to regulate the extent of body bending.

Figure 3

a, Model showing that body bending locally stretches the plasma membrane of the DVA axon, potentially activating TRP-4 channels. Ovals depict TRP-4; arrows indicate the local stretch resulting from body bending. b, Second model proposing that the negative regulator TRP-4 acts together with an unknown positive factor in DVA to modulate the extent of muscle contraction. c, d, Snapshot images of a moving trp-4(sy695) worm (c; duplicate of Fig. 1d), and a moving DVA-ablated trp-4(sy695) worm (d), showing that the exaggerated bending phenotype has been suppressed. e, DVA mediates the exaggerated bending phenotype in trp-4 mutants. Rescue indicates trp-4(sy695) mutants expressing Ex[Ptwk-16(DVA)::trp-4]. Error bars indicate the s.e.m. (n≥8). **P<0.005; *P<0.05.