Figure 1.—

Average departure from Hardy–Weinberg equilibrium at the selected locus, after selection and gene conversion, divided by the average genetic variance at the same locus, as a function of the dominance coefficient of deleterious mutations h (the right side is a blow-up of the left). Curves correspond to analytical predictions from Equation 2 for different parameter values. Solid curve, deterministic limit (), no gene conversion (γ = 0), the value of p_A at mutation–selection equilibrium is obtained by solving –sp_A[h + (1 – 2h)p_A] + u = 0; dashed curve, N = 20,000, γ = 0; dotted curve, N = 20,000, γ = 10⁻⁴. For both the dashed and dotted curves, 〈pq_A²〉/〈pq_A〉 is obtained by numerical integration over Wright's distribution, , where K is a constant. Squares and circles: simulation results for N = 20,000, γ = 0 (squares) and N = 20,000, γ = 10⁻⁴ (circles). Other parameter values: s = 0.05, σ = 0.5, u = 10⁻⁵, v = 10⁻⁶.