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. Author manuscript; available in PMC: 2010 May 10.
Published in final edited form as: Circ Heart Fail. 2010 Jan 27;3(2):294–305. doi: 10.1161/CIRCHEARTFAILURE.109.903450

Figure 5.

Figure 5

BFT activates the pentose phosphate pathway and inhibits reactive oxygen species. Bar graphs showing the effect of BFT on transketolase (A), glucose-6-phosphate dehydrogenase (G6PD) (B), GADPH (C), and AGE (D) (n=5 per group, each assay in triplicate). Representative microphotographs and bar graphs showing myocardial hydroxyl radical levels (E) (n=5 per group). Treatment duration and statistical analysis as in Figure 3. 8-OHDG indicates 8-hydroxydeoxyguanosine. *P<0.01, **P<0.001, and ***P<0.0001 versus healthy controls in type 1 DM or db/+ mice in type 2 DM; #P<0.001, ##P<0.001, and ###P<0.01 versus vehicle-treated diabetic mice in type 1 DM or db/db mice in type 2 DM.