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Attenuation of cocaine priming effects on extinguished drug-seeking behavior after pretreatment with either 0.3 mg/kg spiradoline (white triangles) or 0.01 mg/kg enadoline (gray diamonds) compared to vehicle pretreatment. Points above “alone” show response rates following the kappa agonists alone. Data are means ± S.E.M. from six monkeys. * indicates significant differences relative to vehicle (p < 0.05).
