Table I.

Mayo Clinic CLL cases with a 13q- FISH abnormality, comparing 13q-x1 versus 13q-x2, versus mosaic FISH patterns.

	13q-x1 (n=194)		13q-x1/13q-x2 (n=68)		13q-x2 (n=61)		p-value
	N	%	N	%	N	%
Age							0.04
Mean (std dev)	61.3	11.1	61.6	10.5	65.3	10.3
Median, range	61	37–87	60.5	43–90	66	46–87
Gender							0.08
Female	74	38	32	47	17	28
Male	120	62	36	53	44	72
Rai Stage							0.30
Low (0)	98	56	44	70	37	66
Intermediate (1 or 2)	65	37	18	29	17	30
High (3 or 4)	11	6	1	2	2	4
Unknown	20		5		5
CD38							0.17
Positive	24	13	5	8	3	5
Negative	161	87	61	92	55	95
Missing	9		2		3
ZAP-70							0.79
Positive	38	25	12	21	11	22
Negative	112	75	45	79	38	78
Missing	44		11		12
IgVH							0.28
Unmutated	33	26	7	15	9	21
Mutated	95	74	41	85	33	79
Missing	66		20		19