Estimated cumulative incidences of proliferative retinopathy or worse (A), nephropathy (B), and cardiovascular disease (C) over time. Nephropathy was defined as an albumin excretion rate of 300 mg/24 h or higher, a serum creatinine level of 2 mg/dL or higher, or dialysis or renal transplant. Cardiovascular disease was defined as described in the “Clinical Outcomes” subsection of the “Methods” section. DCCT/EDIC indicates Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications; EDC, Pittsburgh Epidemiology of Diabetes Complications.