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. Author manuscript; available in PMC: 2011 May 13.
Published in final edited form as: J Med Chem. 2010 May 13;53(9):3685–3695. doi: 10.1021/jm100057h

Table 3.

Half-lives (t1/2) of the test articles in the presence of pooled human microsomes.

Compound t1/2, 1 μM (min) t1/2, 10 μM (min)
CQ 749 NCa
1 374.7 255.6
2 116.2 NC
3 116.3 3378.5
4 48.2 108.9
5 13.8 13
6 12 17.7
7 11.8 29.3
8 8.5 29.2
9 7.7 14.1
10 7.5 37.1
11 6.9 8.7
12 6.9 8.2
13 6.7 8.2
14 6.4 29.5
15 6.3 8.8
16 5.6 38.4
17 5.5 8.6
18 94.8 276.2
19 147.6 160.8
20 408.4 NC
a

NC = not calculated owing to insufficient decrease in parent compound.