. Author manuscript; available in PMC: 2011 May 13.

Published in final edited form as: J Med Chem. 2010 May 13;53(9):3685–3695. doi: 10.1021/jm100057h

Table 6.

Pharmacokinetic profile in mice following a single oral dose.

Compound	Dose PO (mg/kg)	t_1/2 (h)	t_max (h)	C_max (nM)	AUC_last (pmole·h/ml)	Relative Bioavailability (F_rel^a)
CQ	50	5.5	0.5	444.3	2639.29	NA
1	50	3.1	0.5	261.4	725.77	0.25
4	50	15.9	0.5	436.6	6792.42	2.34
18	50	6.8	2	240.2	2026.66	0.70
20	50	4.8	4	65.9	620.49	0.21

Relative Bioavailability (F_rel) = AUC_{last, test}/AUC_{last, CQ}