TABLE 2.

Factors associated with hot flash bother, adjusting for hot flash frequency

	Hot flash bother
Factor	Minimally adjusted OR (95% CI)	Fully adjusted OR (95% CI)
No. of hot flashes/week	1.06 (1.05–1.08)e	1.07 (1.05–1.08)e
Negative affecta	1.40 (1.20–1.64)e	1.27 (1.08–1.51)d
Symptom sensitivitya	1.23 (1.07–1.41)d	1.18 (1.03–1.37)c
Sleep problems	1.37 (1.03–1.81)c	1.38 (1.04–1.85)c
No. of visits reporting hot flashes	1.16 (1.08–1.25)e	1.14 (1.06–1.23)d
Age	—	0.94 (0.89–0.99)c
Race/ethnicity
African American	—	1.59 (1.12–2.26)c
Chinese		0.47 (0.23–0.98)b
Japanese		0.57 (0.30–1.12)
White		Reference
Poorer self-rated healtha	—	1.24 (1.03–1.48)c
Education	—
≤ High school		0.84 (0.57–1.24)
Some college/vocational		0.96 (0.65–1.43)
≥College		Reference
Antidepressant use	—	1.35 (0.94–1.95)
BMIa	—	1.01 (0.99–1.03)

Models adjusted for site and covariates as listed. BMI, body mass index; OR, odds ratio.

^aOR associated with every 1-SD increase.

^bP < 0.10;

^cP < 0.05;

^dP < 0.01;

^eP < 0.0001.