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. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Mar 24;20(10):3177–3181. doi: 10.1016/j.bmcl.2010.03.064

Scheme 1. Synthesis of 19–25.

Scheme 1

Reagents and conditions: (a) Triethylamine, Ethyl acetate, reflux, 25min; (b) Na, MeOH, Formamide, 150°C, 12 h.; (c) Phosphorous oxychloride, reflux, 3h; (d) Isopropanol, 2–3 drops concd HCl (except for 25), reflux