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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Chem Biol Drug Des. 2009 Sep;74(3):246–257. doi: 10.1111/j.1747-0285.2009.00855.x

Table 2.

Antiproliferative activity of compounds studied in three cancer cell lines

Code No. Structure HCT116 IC50 μM MCF-7 IC50 μM SKBR-3 IC50 μM
HERP1
 Arg-Tyr
 >100
 >100
 >100
HERP2
 Arg-Pro-Tyr
 >100
 >100
 >100
HERP3
 Arg-Tyr-Trp-Tyr-Gly
 >100
 >100
 >100
HERP4
 Arg-Phe
 >100
 >100
 >100
HERP5
 H-Arg-[(R,S)3-amino-3-(1-napthyl)-propionic acid]-Phe-OH
 25.7
 16.9
 0.396
HERP6
 4-(N'-hydroxycarbamimidoyl)-N-[ 3-methoxy-5-(4-methoxystyryl) phenyl ] benzamide
 11.9
 9.2
 1.62
HERP7 24.7 13.2 0.143
(S)-2-(4-hydroxyphenethylamino)-1(4-benzyloxy)phenyl)propan-1-one

IC50 (n = 6, standard error 1.1) for HCT 116 cells; (n = 4, standard error 1.0) for MCF 7 cells; and (n = 4, standard error 0.022) for HERP5 and HERP7 for SKBR3 cells.