A diet containing sucrose, but not TAG, promotes the development of obesity in male and female LDLr−/− mice. (a) Male and (b) female SUCR-fed mice exhibit increased body weight compared to TAG and CONTROL mice. Beginning on week 7 in males and week 11 in females, body weight was greater in SUCR-fed mice compared to TAG and CONTROL. Data are mean ± s.e.m. from N = 5–6 mice/ gender. Accordingly, (c) male and (d) female SUCR-fed mice exhibit increased energy intake compared to both CONTROL and TAG mice (*P < 0.001). LDLr−/−, low-density lipoprotein receptor deficient.