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. Author manuscript; available in PMC: 2010 May 10.
Published in final edited form as: Gastroenterology. 2008 Sep 4;135(4):1079–1099. doi: 10.1053/j.gastro.2008.07.076

Figure 5.

Figure 5

Schematic diagram of cell cycle checkpoints in relation to cell cycle phases. The DNA damage, DNA replication, and mitotic/spindle-kinetochore checkpoints are shown with a corresponding list of a subset of human and S cerevisiae genes that function at each of the checkpoints. The sensor proteins and downstream signal transduction and effector proteins are listed for the DNA replication checkpoints in S phase. The proteins listed at the other checkpoints operate as sensor, transducers, or effector proteins.