Table 4.
Selected Genes Affected by Aberrant Methylation in Colorectal Cancer
| Gene | CIMP association | Age-related methylation vs cancer-related methylation | Concurrent mutations | Methylation frequency in colorectal cancer (%) |
|---|---|---|---|---|
| MLH1 | CIMP1 | C-type |
BRAF V600E MSI |
10–20 |
| TIMP3 | CIMP1 | C-type |
BRAF V600E MSI |
20–30 |
| MINT17 | CIMP1 |
BRAF V600E MSI |
— | |
| P14 | CIMP1 | C-type |
BRAF V600E MSI |
10–20 |
| RIZ1 | CIMP1 | C-type |
BRAF V600E MSI |
10–20 |
| CDKN2A | CIMP1 | C-type |
BRAF V600E MSI |
20–30 |
| MINT12 | CIMP1 |
BRAF V600E MSI |
20–40 | |
| RUNX3 | CIMP1 and “New”/Laird | C-type |
BRAF V600E MSI |
>20 |
| SOCS1 | CIMP1 and “New”/Laird | C-type |
BRAF V600E MSI |
20 |
| MINT1 | CIMP1 and CIMP2 | 0–20 | ||
| MINT31 | CIMP1 and CIMP2 | 0–20 | ||
| MINT27 | CIMP2 | KRAS mutant | — | |
| MSS/MSI-L | ||||
| MINT2 | CIMP2 | KRAS mutant | 0–20 | |
| MSS/MSI-L | ||||
| MEGALIN | CIMP2 | C-type | KRAS mutant | 10–20 |
| MSS/MSI-L | ||||
| NEUROG1 | CIMP2 and “New”/Laird | C-type | BRAF V600E | 20 |
| CACNA1G | “New”/Laird | C-type | BRAF V600E | 20 |
| IGF2 | “New”/Laird | A-type | BRAF V600E | 100 |
| APC | C-type | 10–20 | ||
| CALCA | C-type | 50 | ||
| MiR342/EVL | C-type | 70–80 | ||
| TSP1 | C-type | 20–30 | ||
| HIC1 | C-type | 50 | ||
| HLTF | C-type | 50 | ||
| VIM | C-type | 60–80 | ||
| MGMT | C-type | 30–40 | ||
| SFRP2 | C-type | 60–80 | ||
| SLC5A8 | C-type | 40–60 | ||
| ESR1 | A-type | >90 | ||
| MYOD1 | A-type | >90 | ||
| N33 | A-type | 80–90 | ||
| PAX6 | A-type | 60–70 | ||
| RASSF1 | A-type | 50 | ||
| RARβ2 | A-type | 10–40 |
A-type, age-related methylation; C-type, cancer-related methylation.