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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Ann Hum Genet. 2010 Feb 18;74(2):110–116. doi: 10.1111/j.1469-1809.2010.00566.x

Table 3.

Multivariate association analyses using the CMC approach.

Gene N (% complete data) P*
CSRP3 366 (78.5) 0.52
LDB3 232 (49.8) 0.42
MYH7 165 (35.4) 0.03
SCN5A 175 (37.6) 0.96
TCAP 397 (85.2) 0.09
TNNT2 275 (59.0) 0.93

Rare variants (MAF≤0.03) were collapsed into two binary indicators of the presence or absence of any rare variants of a given type (either “non-synonymous, frameshift, and truncation” or “other”) in a gene. Common variants were scored for the number of minor alleles. Multivariate analysis was performed using Hotelling’s T2 test to compare the mean minor allele counts and binary indicators between cases and controls simultaneously across all common and rare sites in a given gene.