Table 3.
Gene | N (% complete data) | P* |
---|---|---|
CSRP3 | 366 (78.5) | 0.52 |
LDB3 | 232 (49.8) | 0.42 |
MYH7 | 165 (35.4) | 0.03 |
SCN5A | 175 (37.6) | 0.96 |
TCAP | 397 (85.2) | 0.09 |
TNNT2 | 275 (59.0) | 0.93 |
Rare variants (MAF≤0.03) were collapsed into two binary indicators of the presence or absence of any rare variants of a given type (either “non-synonymous, frameshift, and truncation” or “other”) in a gene. Common variants were scored for the number of minor alleles. Multivariate analysis was performed using Hotelling’s T2 test to compare the mean minor allele counts and binary indicators between cases and controls simultaneously across all common and rare sites in a given gene.