TABLE 1.
Patient demographic data
| Variable | All transplant patients (n=342) |
Developed post-transplant malignancy |
|
|---|---|---|---|
| No (n=283) | Yes (n=58) | ||
| Female sex | 143 (42) | 116 (41) | 27 (46) |
| Male sex | 199 (58) | 167 (59) | 31 (54) |
| Indication for transplant | |||
| Emphysema | 118 (35) | 99 (35) | 19 (32) |
| Pulmonary fibrosis | 56 (16) | 41 (14) | 15 (25) |
| Cystic fibrosis | 52 (16) | 44 (16) | 8 (14) |
| Alpha 1 antitrypsin deficiency | 40 (12) | 34 (12) | 6 (10) |
| Secondary pulmonary hypertension | 14 (4) | 13 (5) | 1 (2) |
| Primary pulmonary hypertension | 14 (4) | 11 (4) | 3 (5) |
| Talcosis | 14 (4) | 12 (4) | 2 (3) |
| Other | 34 (10) | 29 (10) | 5 (8.5) |
| Type of transplant | |||
| Double lung | 232 (68) | 195 (69) | 37 (63) |
| Left lung | 44 (13) | 37 (13) | 7 (12) |
| Right lung | 41 (12) | 29 (10) | 12 (20) |
| Heart lung | 25 (7) | 22 (8) | 3 (5) |
| Living donor | 5 (1) | 4 (1) | 1 (0) |
| Recipient history | |||
| Smoking history, pack-years | 234 (69) | 194 (69) | 40 (69) |
| 0–10 | 18 (5.3) | 14 (5) | 4 (8) |
| 11–20 | 34 (10) | 27 (10) | 7 (12) |
| >20 | 182 (53) | 153 (54) | 29 (49) |
| Diabetes | 20 (6) | 17 (6) | 3/20 (15) |
| Body mass index >30 kg/m2 | 197/311 (63.3) | 169 (58) | 28 (55) |
| Previous malignancy | 21 (6) | 16 (5) | 6 (12) |
| Donor | |||
| Male sex | 151 (49) | 144 (49) | 24 (47) |
| Female sex | 174 (51) | 147 (51) | 27 (51) |
| History of diabetes | 10 /332 (2.9) | 8 (3) | 2 (2) |
| Smoking, pack-years | 172 (50) | 68 (24) | 17 (29) |
| 0–10 | 95 (29) | 17 (29) | 68 (24) |
| 11–20 | 36 (11) | 5 (8) | 31 (11) |
| >20 | 182 (56) | 11 (19) | 40 (14) |
| History of cancer* | 7 (2) | 2 (3.3) | 5 (1.8) |
| Serology | |||
| Recipient Epstein-Barr virus seronegativity | 30/327 (9.2) | 21/270 (7.8) | 4/49 (18) |
| Epstein-Barr virus mismatch | 136 (40) | 108 (38) | 28 (47) |
| Herpes simplex virus mismatch | 261/340 (76) | 210/281 (75) | 51/59 (86) |
| Cytomegalovirus mismatch | 161 (47) | 139 (49) | 22 (37) |
Data are presented as n (%).
*
Donor history of cancer included only benign lesions in the central nervous system and squamous cell carcinoma or basal cell carcinoma