Figure 5.

Comparing conformational changes upon ligand-binding (left column) to the buried tertiary RIP couplings (right column). In the left column, bright red is Cα RMSD = 15 Å between the apo and holo structures. In the right column, buried tertiary residues that are involved in RIP couplings are shown in red. (A,B) PSD95-PDZ3; (C,D) PTP-PDZ2; (E,F) PAR6-PDZ; (G,H) INAD-PDZ5; (I,J) GRIP1-PDZ7. The buried tertiary couplings are significantly different across the 5 domains. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]