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The same contact in the PDZ fold across different PDZ domains (corresponds to Pair 17 in Table 1). (A) PSD95-PDZ3, (B) PTP-PDZ2, (C) PAR6-PDZ, (D) INAD-PDZ5, and (E) GRIP1-PDZ7. The contacts in (C) and (D) are RIP-coupled, whilst the other three are not. The coupling depends on the orientation of the χ angles and is not obvious from inspection of the contacts or accessible surface-area. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]
