Table 1.
Effect of atropine on heart rate, mean arterial pressure and indices of heart rate variability
| Strain | Control heart rate (bpm) |
Atropine heart rate (bpm) |
Control MAPa (mm Hg) |
Atropine MAP (mm Hg) |
Control SDNNb (ms) |
Atropine SDNN (ms) |
Control SDSDc (ms) |
Atropine SDSD (ms) |
Control PI90d (ms) |
Atropine PI90 (ms) |
|---|---|---|---|---|---|---|---|---|---|---|
| Mecp2+/+ | 620 ± 26 | 669 ± 16 | 115 ± 4 | 111 ± 4 | 7.7 ± 0.6 | 3.9* ± 0.5 | 7.8 ± 1.0 | 4.6* ± 0.6 | 25.1 ± 2.1 | 11.8* ± 1.8 |
| Mecp2+/− | 586 ± 26 | 672* ± 11 | 101 ± 5 | 104 ± 3 | 7.6 ± 0.5 | 3.7* ± 0.9 | 7.3 ± 1.0 | 5.3 ± 0.6 | 24.3 ± 1.4 | 11.4* ± 1.3 |
Values are mean ± S.E. N = 6 for both strains.
*
significantly different from control, p values between 0.024 and <0.0001. There are no differences between strains.
a
mean arterial pressure;
b
standard deviation of pulse interval;
c
standard deviation of adjacent pulse intervals;
d
range encompassing 90% of pulse intervals.