Table 2.
Effect of propranolol on heart rate, mean arterial pressure and indices of heart rate variability
| Strain | Control heart rate (bpm) |
Propranolol heart rate (bpm) |
Control MAPa (mm Hg) |
Propranolol MAP (mm Hg) |
Control SDNNb (ms) |
Propranolol SDNN (ms) |
Control SDSDc (ms) |
Propranolol SDSD (ms) |
Control PI90d (ms) |
Propranolol PI90 (ms) |
|---|---|---|---|---|---|---|---|---|---|---|
| Mecp2+/+ | 596 ± 24 | 506* ± 13 | 108 ± 3 | 111 ± 2 | 9.6 ± 1.7 | 4.0* ± 0.4 | 8.9 ± 2.1 | 5.1 ± 0.7 | 26.5 ± 2.1 | 12.1 ± 0.9* |
| Mecp2+/− | 620 ± 22 | 504* ± 25 | 114 ± 6 | 119 ± 5 | 7.4 ± 0.6 | 5.0* ± 0.9 | 8.5 ± 1.5 | 6.6 ± 1.5 | 24.3 ± 2.2 | 15.2 ± 2.6* |
Values are mean ± S.E. N = 7 for both strains.
*
significantly different from control, p values between 0.043 and 0.0002. There are no differences between strains.
a
mean arterial pressure;
b
standard deviation of pulse interval;
c
standard deviation of adjacent pulse intervals;
d
range encompassing 90% of pulse intervals.