Figure 2.

Temporal adaptation of intact diaphragm (DPH) muscle contractile function in diabetic muscles. All data are presented as the mean ± SD. (a) Diabetes exerts an acute deleterious effect on DPH contractile function that is reverted with time (b and c) and profoundly deteriorates with the progression of diabetes (d). After 2 weeks of insulin treatment DPH contractile function significantly improves to levels comparable to control levels (d). In all panels, closed squares show data for control muscles, open circles for diabetic muscles, and the open triangle represents the diabetic + insulin treatment. * means P < .05. T_max, number of experiments and statistical details are presented in Table 1 and methods.