Skip to main content
. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Mol Pharm. 2009 Nov–Dec;6(6):1836–1847. doi: 10.1021/mp900134c

FIGURE 3.

FIGURE 3

Biodistribution of 125I-labeled HPMA copolymer conjugates P1 (panel A) and P2 (panel B) given at 60 mg/kg drug equivalent dose in non tumor-bearing mice. Activity per organ is expressed as % injected dose per gram of tissue (%ID/g) following necropsy at 15 min, 1, 6, 24, 48 and 72 h post-intravenous injection. Rapid decrease in blood is accompanied by decreasing activity in organs. Significantly higher prolonged activity of conjugate P1 occurs in kidney compared to the non-targeted polymer P2 (B) and is indicated on the graph as * p<0.001. Data is expressed as mean ±SD.