TABLE 1.
Physicochemical characteristics of HPMA copolymer conjugates*
| Sample | P1 | P2 | |
|---|---|---|---|
| Structure | P-(GFLG-AH-GDM)- (GG-RGDfK) |
P-(GFLG-AH-GDM)- (GG-OH) |
|
| Estimated Mw (kDa) a | 28.4c | 28.4 | |
| Mw/Mna,b | 1.7 | 1.7 | |
| AH-GDM content d | mmol/g | 0.239 | 0.239 |
| % wt/wt | 15.4 | 15.4 | |
| RGDfK content e | mmol/g | 0.361 | -- |
| peptides/backbone f | 10.1 | -- |
a
As determined by size exclusion chromatography.
b
Polydispersity.
c
Reported as precursor Mw.
d
Results of UV spectrophotometric analysis.
e
Results of amino acid analysis.
f
Average as estimated from molecular weight and amino acid analysis data.
*
For structure see Figure 1