TABLE 3.
Tumor-to-background ratios for HPMA copolymer-AH-GDM conjugates with and without RGDfK
| 1 h | 24 h | 48 h | 72 h | |
|---|---|---|---|---|
| HPMA-AH-GDM-RGDfK (P1) | ||||
|
| ||||
| Blood | 0.49 | 7.66 | 15.43 | 18.04 |
| Heart | 0.98 | 16.50 | 21.94 | 23.04 |
| Lung | 0.50 | 5.97 | 6.32 | 7.25 |
| Liver | 0.20 | 1.21 | 1.95 | 2.24 |
| Kidney | 0.10 | 0.73 | 0.59 | 0.57 |
| Spleen | 0.94 | 6.94 | 6.26 | 5.61 |
| Small Intestine | 0.13 | 1.51 | 3.51 | 6.97 |
| Large Intestine | 0.24 | 0.96 | 3.41 | 7.25 |
| Stomach | 0.19 | 1.72 | 4.13 | 12.53 |
|
| ||||
| HPMA-AH-GDM (P2) | ||||
|
| ||||
| Blood | 0.35 | 0.64 | 1.21 | 1.18 |
| Heart | 1.12 | 1.66 | 1.43 | 1.29 |
| Lung | 0.66 | 0.82 | 0.65 | 0.65 |
| Liver | 0.47 | 0.17 | 0.11 | 0.12 |
| Kidney | 0.15 | 0.07 | 0.05 | 0.03 |
| Spleen | 1.04 | 0.94 | 0.40 | 0.71 |
| Small Intestine | 0.42 | 0.38 | 0.62 | 1.13 |
| Large Intestine | 0.83 | 0.28 | 0.47 | 0.89 |
| Stomach | 0.21 | 0.26 | 0.62 | 0.71 |