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. 2010 Apr 23;8(4):1469–1481. doi: 10.3390/md8041469

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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Compound 6 induces morphological changes representative of apoptosis. Cell apoptosis induced by compound 6 was examined by Hoechst 33258 staining and observed under fluorescence microscope at 400 × magnification. KB cells and KBv200 cells were treated with compound 6 of 12.0 μM for 48 h. The apoptotic cells detected by the fluorescence microscopy displayed typical changes of apoptosis including staining bright of condensed or fragmented nucleus. Herein, treatment with adriamycin (0.1 μM for KB cells and 7.0 μM for KBv200 cells) for 48 h was included as the positive control.