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. 2010 Apr 14;30(15):5357–5367. doi: 10.1523/JNEUROSCI.5017-09.2010

Figure 2.

Figure 2.

Basal and stress-induced depression-related phenotypes in seven strains. A, Repeated stress reduced body weight, relative to nonstressed controls over the same period, in all strains except 129S1/SvImJ (n = 5–20 per strain under stress) (*p < 0.05 vs nonstress/same strain). B, BALB/cByJ, but no other strain, showed less immobility after stress compared to no stress. Under nonstressed conditions, DBA/2J and FVB/NJ were more mobile than C57BL/6J (n = 7–9 per strain under stress; *p < 0.05 vs nonstressed BALB/cByJ; #p < 0.05 vs nonstressed C57BL/6J). C, Regardless of prior restraint stress, swim stress increased serum corticosterone levels in all strains, relative to nonswim/nonrestrained controls (*p < 0.05 vs nonrestrained/same strain). Restraint stressed C57BL/6J and DBA/2J had a higher swim-stress-induced corticosterone response than nonrestrained counterparts. Restrained 129S1/SvImJ had a lower swim-stress-induced corticosterone response than nonrestrained counterparts (†p < 0.05 vs nonrestrained/swim stressed/same strain; n = 5–15 per strain under stress). Data are expressed as mean ± SEM.