Table 2. Average Efflux (% per 4h) For Serum Specimens From Females With HDL-C= 73 ± 6% (HDL-C=69-77).
Mean ± SEM | ||||
---|---|---|---|---|
Efflux Pathway | Cell Model | Efflux Below Mean (n=9) | Efflux Above Mean (n=9) | P Value |
Total J774 | J774+ cAMP | 11.7±0.4 | 15.0±0.5 | <0.0001 |
Uninhibited Efflux | J774+ cAMP | 4.6±0.2 | 5.7±0.3 | 0.0102 |
SR-BI | J774+ cAMP | 1.4±0.2 | 1.4±0.3 | NS |
ABCA1 | J774+ cAMP | 6.2±0.5 | 8.5±0.5 | 0.0072 |
ABCG-1 | G1-BHK | 2.7±0.3 | 2.6±0.3 | NS |
Efflux values to the serum apoB-depleted serum are given as Mean ± SEM. Mean total J774 efflux for all sera analyzed (n=18) =13.4% per 4h (10.2-17.6). Average total HDL-C in each group was 73 which represents the 75th percentile for the range of HDL-C values in this set of serum specimens from all female donors (n=130).