Table 3.
Association Between Pulmonary Scarring Detected by Baseline Chest Radiography and Subsequent Risk of Lung Cancer
| Lung Cancers With Scarring, No. (%) | Lung Cancer With Scarring in the Same/Opposite Lung, No./No.a | Risk of Lung Cancer Associated With Scarring, HR (95%CI)b |
||||
|---|---|---|---|---|---|---|
| Category | Lung Cancer Cases, No. | Overall | Ipsilateral Lung Cancer | Contralateral Lung Cancer | ||
| All lung cancer | 809 | 122 (15.1) | 91/75 | 1.5 (1.2-1.8) | 1.8 (1.4-2.4) | 0.9 (0.7-1.2) |
| Histologic subtype of lung cancer | ||||||
| Adenocarcinoma | 349 | 54 (15.5) | 40/30 | 1.6 (1.2-2.2) | 2.1 (1.4-3.2) | 0.8 (0.5-1.3) |
| Squamous cell carcinoma | 152 | 24 (15.8) | 21/20 | 1.3 (0.8-2.0) | 1.5 (1.0-2.4) | 1.4 (0.9-2.1) |
| Small cell carcinoma | 107 | 13 (12.1) | 9/7 | 1.2 (0.6-2.1) | 1.7 (0.8-3.6) | 0.7 (0.3-1.6) |
| Follow-up interval after baseline, y | ||||||
| 0.01-2.00 | 268 | 37 (13.8) | 28/24 | 1.3 (0.9-1.8) | 1.6 (1.0-2.6) | 0.9 (0.5-1.5) |
| 2.01-4.00 | 220 | 34 (15.5) | 27/21 | 1.5 (1.1-2.2) | 2.0 (1.2-3.3) | 0.8 (0.5-1.5) |
| 4.01-6.00 | 143 | 24 (16.8) | 17/13 | 1.8 (1.1-2.8) | 2.1 (1.1-4.0) | 0.8 (0.5-1.4) |
| 6.01-12.00 | 178 | 27 (15.2) | 19/17 | 1.6 (1.1-2.4) | 1.7 (0.9-3.2) | 1.0 (0.5-2.0) |
Abbreviations: CI, confidence interval; HR, hazard ratio.
a
Persons with bilateral scarring or bilateral cancer were counted as having scarring both in the same and in the opposite lung as the cancer. Persons with missing location data on scarring or cancer were not counted in these categories.
b
Hazard ratios are adjusted for age, sex, race/ethnicity, and smoking.