Table 3.
Cases (n = 1,176) | Controls (n = 1,101) | ORa | 95% CI | |
---|---|---|---|---|
T1D risk allele count (%) | ||||
7-12 | 27.41 | 27.43 | 1.00 | Ref |
13-14 | 32.02 | 32.24 | 0.97 | 0.78-1.20 |
15 | 17.25 | 16.17 | 1.07 | 0.83-1.37 |
16-22 | 23.31 | 23.16 | 1.01 | 0.80-1.27 |
p-trend = 0.78 | ||||
T1D relative risk (%) | ||||
0.07-0.28 | 25.28 | 24.70 | 1.00 | Ref |
0.29-0.46 | 25.79 | 24.34 | 1.05 | 0.83-1.33 |
0.47-0.89 | 25.45 | 24.34 | 1.02 | 0.81-1.29 |
0.90-42.9 | 23.48 | 26.61 | 0.86 | 0.68-1.09 |
p-trend = 0.21 | ||||
T2D risk allele count (%) | ||||
10-16 | 21.18 | 19.35 | 1.00 | Ref |
17-18 | 28.69 | 26.70 | 0.99 | 0.77-1.25 |
19-20 | 28.78 | 28.52 | 0.93 | 0.73-1.18 |
21-27 | 21.35 | 25.49 | 0.77 | 0.60-0.99 |
p-trend = 0.03 | ||||
T2D relative risk (%) | ||||
0.26-0.76 | 25.70 | 24.25 | 1.00 | Ref |
0.77-1.01 | 25.96 | 23.98 | 1.03 | 0.82-1.30 |
1.02-1.36 | 24.85 | 25.16 | 0.94 | 0.74-1.18 |
1.37-5.44 | 23.48 | 26.61 | 0.85 | 0.70-1.07 |
p-trend = 0.11 | ||||
T2D risk allele count (excluding HNF1B; %) | ||||
10-15 | 19.04 | 18.53 | 1.00 | Ref |
16-17 | 29.97 | 27.52 | 1.06 | 0.83-1.35 |
18-19 | 28.95 | 29.79 | 0.94 | 0.74-1.21 |
20-26 | 22.08 | 24.16 | 0.88 | 0.69-1.14 |
p-trend = 0.20 | ||||
T2D relative risk (excluding HNF1B; %) | ||||
0.28-0.77 | 25.53 | 24.43 | 1.00 | Ref |
0.78-1.01 | 25.79 | 24.16 | 1.03 | 0.82-1.30 |
1.02-1.37 | 24.59 | 25.43 | 0.93 | 0.73-1.17 |
1.38-5.45 | 24.08 | 25.98 | 0.90 p-trend | 0.71-1.14 = 0.26 |
ORs and 95% CI are adjusted for categorical age and genetic ancestry.