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. 2010 Mar 5;69(3):193–201. doi: 10.1159/000289594

Table 4.

Associations between T1D and T2D risk variants and PCa risk

Gene SNP Risk allele Risk allele frequency
 Age- and ancestry-adjusted (sorted by OR)
cases controls ORa 95% CI p valueb
T1D
 PTPN2 rsl893217 G 0.146 0.159 0.90 0.76-1.05 0.17
 CLEC16A rs2903692 G 0.628 0.650 0.91 0.80-1.02 0.12
 ERBB3 rsl701704 C 0.328 0.341 0.93 0.82-1.05 0.28
 HLA rs9275184 C 0.098 0.104 0.93 0.77-1.13 0.53
 IFIH1 rsl990760 A 0.601 0.613 0.94 0.83-1.06 0.25
 PTPN22 rs2476601 T 0.092 0.096 0.95 0.78-1.15 0.51
 INS rsl004446 C 0.621 0.630 0.97 0.86-1.09 0.61
 IL2/IL21 rs4505848 A 0.656 0.662 0.99 0.87-1.11 0.81
 C1QTNF6 rs229527 A 0.422 0.427 0.99 0.88-1.12 0.87
 PRKCQ rs947474 A 0.812 0.810 1.01 0.87-1.18 0.80
 CTSH rs2870085 C 0.682 0.670 1.06 0.93-1.20 0.37
 C12orf30 rsl7696736 G 0.454 0.438 1.07 0.95-1.21 0.25
 BACH2 rs3757247 A 0.489 0.461 1.12 1.00-1.26 0.06
 IL2RA rsl2251307 C 0.893 0.877 1.17 0.97-1.40 0.10
T2D
 FTO rs8050136 A 0.391 0.423 0.87 0.77-0.98 0.02
 HNF1B rs4430796 G 0.459 0.498 0.87 0.77-0.97 0.02
 NOTCH2c rs2641348 G 0.096 0.109 0.87 0.71-1.05 0.14
 PPARG rs6802898 C 0.852 0.868 0.88 0.74-1.04 0.14
 KCNQ1 rs2237892 C 0.931 0.940 0.88 0.69-1.12 0.30
 KCNJ11 rs5215 C 0.347 0.373 0.89 0.78-1.00 0.07
 IGF2BP2 rs4402960 T 0.300 0.321 0.91 0.81-1.04 0.16
 CDKN2A/B rs2383208 A 0.802 0.810 0.95 0.82-1.10 0.47
 SLC30A8 rsl3266634 C 0.699 0.705 0.97 0.86-1.11 0.70
 TCF7L2 rs7903146 T 0.287 0.298 0.97 0.85-1.10 0.66
 HHEX rsllll875 C 0.586 0.592 0.98 0.87-1.10 0.79
 JAZF1c rsl635852 T 0.490 0.495 0.98 0.87-1.10 0.69
 ADAMTS9c rs4411878 C 0.746 0.748 0.98 0.85-1.12 0.74
 CDKAL1 rs7756992 G 0.280 0.282 1.00 0.88-1.14 0.99
 WFS rsl0012946 C 0.597 0.594 1.02 0.91-1.15 0.81
 CDC123c rsll257655 T 0.208 0.202 1.03 0.89-1.19 0.67
 TSPAN8c rsl353362 C 0.274 0.264 1.04 0.92-1.19 0.52
 THADAc rsl3414140 C 0.885 0.874 1.10 0.92-1.32 0.30
a

Per-allele ORs are adjusted for categorical age and ancestry and calculated using the non-risk alíele as the reference group

b

p value is derived from an Armitage test of trend

c

SNPs identified in a previous meta-analysis.