Fig. 5.

Action of antagonist of VR1 receptors, SB 366791 and rescue compounds, on development of S. droebachiensis embryos. All substances were given at the mid-blastula 2 stage (17 h, 21 min post-fertilization). Specimens were imaged at 26 h, 35 min (A–F) or 42 h 05 min (G–L) after fertilization. A, G Control embryos/larvae; B, H SB366971 1.25 μM (abnormal development); C, I SB366971 + AA-5-HT 40 μM (normal development); D, J; E, K SB366971 + arvanil 40 μM or AM-251 10 μM (good protection); F, L SB366971 + forskolin 20 μM (moderate protection). Temperature during experiments 14 °C. Scale bar = 50 μm (A–F) or 100 μm (G–L).