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Dose-dependent malformation phenotypes caused by CB receptor agonists. Dose-dependent malformations caused by different doses of CB receptor agonists, anadamide (AEA), CP55940 (CP), and WIN55212-2 (WIN) given at the 2-cell stage show order of teratogenicity (CP > WIN > AEA) that fits their pharmacologic potency profiles in vertebrates [Breivogel and Childers, 2000; Prather et al., 2000; Palmer et al., 2002].
