Table 2.

Morphology and molecular characteristics of the human neuroblastoma cell lines studied

Cell line	Morphology	MYCNa	Karyotypeb	LOH 1pc	References
LAN-1	N	Amp	87	+	[22,24,27,28]
LAN-5	Nd	Amp			[29–31]
IMR-32	Ne	Amp (15–20)	49	+	[20–24]
SK-N-SH	N	Not amp (1–2)	47	−	[20,22–24,32,33]
SHSY-5Y	N	Not amp (1–2)	47		[22,28,34]
SMS-KCN	N/S	Amp	46	+	[22,25]
SMS-KCNR	N	Amp	46	+	[22,25]
SMS-KAN	N	Amp (150)	46	+	[9,22,25,26]
SMS-KANR	N	Amp	46	+	[22,25]

^aAmplification of the proto-oncogene MYCN (copy number).

^bModal number of chromosomes.

^cChromosome 1p LOH.

^dNeuroblastic appearance in culture, but no published data available.

^eUniformly neuroblastic appearance in culture, while literature reports both N-type and S-type cells [12].