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. Author manuscript; available in PMC: 2011 Mar 5.
Published in final edited form as: Science. 2010 Mar 5;327(5970):1223–1228. doi: 10.1126/science.1182228

Fig. 2.

Fig. 2

Chronic TOR activation results in accumulation of ROS and dSesn. Larval imaginal discs of indicated strains were stained as indicated. (A) ROS accumulation (red) in response to InRCA or Rheb overexpressed in dorsal (upwards) wing discs was revealed by DHE staining. (B) InRCA-induced ROS (red) accumulation in eye discs was reduced by PI3KDN or TORDN but not by S6KDN or 4E-BPCA. (C) DHE staining (red) in TSC1-negative wing disc clones marked by absence of GFP. (D and E) Inhibition of InRCA-induced accumulation of dSesn (green) in eye and wing discs by expression of catalase or peroxiredoxin (Prx). D-V wing boundary and differentiated eye area were visualized by Wg (red) and Elav (red) staining, respectively. (F) dSesn accumulation (red) in TSC1-negative wing disc clones was suppressed by vitamin E feeding. Absence of GFP (green) indicates loss of TSC1. (G) Diagram depicting TOR-stimulated production of ROS and expression of dSesn.