Table III.
Summary of scale-up considerations for clinical application of a bioartificial liver.
| Hepatic function | Clinical rate (μmol/h) | Hollow fiber surface area (m2) | Hepatocyte rate (μmol/h/g) | Scale-up (grams of hepatocytes) |
|---|---|---|---|---|
| Ammonia detoxification | 400 (Elin, 2007) | 0.3 | 2.6 (Nyberg et al., 2005) | 153 |
| Bilirubin conjugation | 12a | 0.3 | 0.22 (Nyberg, unpublished work) | 55 |
| Albumin synthesis | 6b | 0.3 | 2.0 (Brophy et al., 2009) | 3 |
a
Based on the assumption: 70 kg man, 5 L blood volume, [Hgb] = 10g/dL, 40 mg bili/g Hgb, 120-day life span of red blood cell.
b
Based on the assumption: 70 kg man, 5 L blood volume, [albumin] = 4 g/dL, 15-day life span of albumin.